Cadherin adhesion, tissue tension, and noncanonical wnt signaling regulate fibronectin matrix organization
Dzamba, B., Jakab, K.R., Marsden, M., Schwartz, M.A., and DeSimone, D.W.
(2009) Developmental Cell 16, 421-432
A Mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration
Weber, G.F., Bjerke, M.A., and DeSimone, D.W.
(2012) Developmental Cell 22, 104-115
Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of Xenopus mesendoderm tissue at gastrulation
Sonavane, P.R., Wang, C., Dzamba, B., Weber, G.F., Periasamy, P. and DeSimone D.W.
(2017) Development 144, 4363-4376
Postdoctoral and Predoctoral Training
Please check back here for announcements of open positions and training opportunities at the predoctoral and postdoctoral levels. Prospective students are encouraged to apply to our Biomedical Sciences Graduate Program (BIMS). Existing BIMS students are invited to check out the Cell and Developmental Biology (CDB) Program at UVA and to come by and talk to Doug about lab rotation opportunities.
POSTDOCTORAL RESEARCH ASSOCIATE
The DeSimone laboratory seeks a highly-motivated Postdoctoral Research Associate interested in exploring the importance of mechanical forces in the patterning and morphogenesis of embryos. Our lab has a long-standing interest in mechanisms of cell adhesion and adhesion-dependent cell signaling, and the involvement of these processes in regulating cell and tissue movements, gene expression and cell fate decisions, using Xenopus as a model system. Our research utilizes multiple approaches including live cell imaging, gene-editing, biochemistry and cell biology, and biomechanics. We are looking for a skilled cell and developmental biologist with high enthusiasm for science who will contribute positively to the multidisciplinary, collaborative atmosphere fostered within the DeSimone lab and the Department of Cell Biology.
Department of Cell Biology
University of Virginia
P.O. Box 800732, School of Medicine
Charlottesville, VA 22908
Pinn Hall, room 3229
1340 Jefferson Park Avenue
38o 1' 54.642" N
78o 30' 1.9296" W